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nur77 gfp mouse model  (Jackson Laboratory)

 
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    Jackson Laboratory nur77 gfp mouse model
    Study design. 12–14 week old male <t>Nur77</t> GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .
    Nur77 Gfp Mouse Model, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nur77+gfp+mouse+model/pmc13193879-52-1-15?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    nur77 gfp mouse model - by Bioz Stars, 2026-08
    86/100 stars

    Images

    1) Product Images from "Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes"

    Article Title: Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2026.1703552

    Study design. 12–14 week old male Nur77 GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .
    Figure Legend Snippet: Study design. 12–14 week old male Nur77 GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .

    Techniques Used: Injection, Magnetic Resonance Imaging, Activation Assay, Expressing, Infection



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    nur77 gfp mouse model  (Jackson Laboratory)
    86
    Jackson Laboratory nur77 gfp mouse model
    Study design. 12–14 week old male <t>Nur77</t> GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .
    Nur77 Gfp Mouse Model, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nur77+gfp+mouse+model/pmc13193879-52-1-15?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    nur77 gfp mouse model - by Bioz Stars, 2026-08
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Study design. 12–14 week old male Nur77 GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .

    Journal: Frontiers in Immunology

    Article Title: Targeting T cell metabolism and polarization to modulate post-stroke immune responses and improve outcomes

    doi: 10.3389/fimmu.2026.1703552

    Figure Lengend Snippet: Study design. 12–14 week old male Nur77 GFP mice underwent tMCAO, transient middle cerebral artery occlusion. At the timepoint of reperfusion, mice were injected intraperitoneally with LPS (40 µg/kg) or vehicle (PBS). Two hours after tMCAO and daily in the morning, mice were injected intraperitoneally with Soraphen A (SorA, 2.5 µmol/kg) or vehicle (PEG buffer). Magnetic resonance imaging (MRI) was conducted 16 hours and 7 days after tMCAO to verify infarct induction and calculate lesion volumes. Mice were scored daily and a set of behavioral tests (corner tests, cylinder test and inclined plane test) was conducted before as well as 2 and 6 days after tMCAO. At each experimental time point (16 h, 2 d, 3 d, 7 d after MCAO) brain, lungs, spleen, blood and ingiunal lymph nodes (ILN) were harvested and prepared for flow cytometric analysis of T cell activation and polarization, differentiating between antigen-specific and -unspecific T cell activation via GFP expression. To evaluate the impact of SorA treatment on stroke pathology under post-stroke and post-stroke inflammatory conditions associated with infection, we compared treatment groups to assess: the effect of LPS alone (vehicle/vehicle vs. LPS/vehicle), the effect of SorA alone (vehicle/vehicle vs. vehicle/SorA), and the effect of SorA under proinflammatory conditions (LPS/vehicle vs. LPS/SorA) in MCAO mice. Image created in BioRender. Vogelgesang, A. (2026) https://BioRender.com/pr62lu3 .

    Article Snippet: The Nur77 GFP mouse model was generated by Kristin Hogquist (C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog/J mice, Stock No: 016617, The Jackson Laboratory) ( ) and express eGFP under the control of the Nr4a1 promoter/enhancer regions.

    Techniques: Injection, Magnetic Resonance Imaging, Activation Assay, Expressing, Infection